4-Hydroxyestrone-13C6

• Description :

  4-Hydroxyestrone-13C6 is a 13C-labeled 4-Hydroxyestrone (HY-W009300) . 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].

• Product Name Alternative :

  4-OHE1-13C6

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite; Isotope-Labeled Compounds

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Others

• Assay Protocol :

  https://www.medchemexpress.com/4-hydroxyestrone-13c6.html

• Solubility :

  10 mM in DMSO

• Smiles :

  [13CH3][13C@]12[13C@]([H])([C@]3([C@@]([H])(C4=CC=C(C(O)=C4CC3)O)CC2)[H])[13CH2][13CH2][13C]1=O

• Molecular Formula :

  C12 13C6H22O3

• Molecular Weight :

  292.32

• References & Citations :

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-234.|[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-234.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported