MCB-22-174

CAT: 0804-HY-165607S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-165607S-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MCB-22-174 is a deuterated Piezo1 agonist, with an EC50 value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca2+ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP) [1].
CAS Number
[3058199-58-6]
UNSPSC
12352005
Target
CaMK; ERK; Isotope-Labeled Compounds; Piezo Channel
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Others; Stem Cell/Wnt
Field of Research
Metabolic Disease
Purity
99.78
Smiles
ClC(C=CC=C1Cl)=C1C([2H])SC2=NN=C(C3=NC=C(NC[C@H](O)C)N=C3)S2
Molecular Formula
C16H14DCl2N5OS2
Molecular Weight
429.37
References & Citations
[1]Hao R, et al. A Novel Piezo1 Agonist Promoting Mesenchymal Stem Cell Proliferation and Osteogenesis to Attenuate Disuse Osteoporosis. Small Sci. 2024 Jun 30;4 (9) :2400061.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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