MCB-22-174

• Description :

  MCB-22-174 is a deuterated Piezo1 agonist, with an EC50 value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca2+ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP) [1].

• CAS Number :

  [3058199-58-6]

• UNSPSC :

  12352005

• Target :

  CaMK; ERK; Isotope-Labeled Compounds; Piezo Channel

• Related Pathways :

  MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Others; Stem Cell/Wnt

• Field of Research :

  Metabolic Disease

• Purity :

  99.78

• Smiles :

  ClC(C=CC=C1Cl)=C1C([2H])SC2=NN=C(C3=NC=C(NC[C@H](O)C)N=C3)S2

• Molecular Formula :

  C16H14DCl2N5OS2

• Molecular Weight :

  429.37

• References & Citations :

  [1]Hao R, et al. A Novel Piezo1 Agonist Promoting Mesenchymal Stem Cell Proliferation and Osteogenesis to Attenuate Disuse Osteoporosis. Small Sci. 2024 Jun 30;4 (9) :2400061.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported