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1-Monopalmitin

CAT: 0804-HY-W009141-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-W009141-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp) . 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC50=50-58 μg/mL), with low toxicity to normal cells[1][2].
CAS Number
542-44-9
Product Name Alternative
Glyceryl palmitate
UNSPSC
12352211
Hazard Statement
H302
Target
Akt; Apoptosis; Caspase; IAP; P-glycoprotein; PI3K
Type
Natural Products
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-monopalmitin.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 50 mg/mL (warming; heat to 60°C)
Smiles
OC(CO)COC(CCCCCCCCCCCCCCC)=O
Molecular Formula
C19H38O4
Molecular Weight
330.51
Precautions
H302
References & Citations
[1]Niu L, et al. 1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/A kt pathway in vitro. Environmental Toxicology, 2023, 38 (11) : 2621-2631.|[2]Tomoko Konishi, et al. A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound. Biofactors. 2004;22 (1-4) :71-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

Chemical Information

1-Monopalmitin

1-monopalmitoylglycerol is a 1-monoglyceride that has palmitoyl as the acyl group. A natural product found in Neolitsea daibuensis. It has a role as a plant metabolite and an algal metabolite. It is functionally related to a hexadecanoic acid.

CAS Number542-44-9
PubChem CID14900
IUPAC Name2,3-dihydroxypropyl hexadecanoate
Molecular FormulaC19H38O4
Molecular Weight330.5
XLogP6.3
Topological Polar Surface Area66.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count18
Heavy Atom Count23
Formal Charge0
Complexity256
SMILES
CCCCCCCCCCCCCCCC(=O)OCC(CO)O
InChI
InChI=1S/C19H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)23-17-18(21)16-20/h18,20-21H,2-17H2,1H3
InChIKey
QHZLMUACJMDIAE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Monopalmitin
CAS: 542-44-9
CID: 14900
Formula: C19H38O4
MW: 330.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight330.5
XLogP36.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count18
Exact Mass330.27700969
Monoisotopic Mass330.27700969
Topological Polar Surface Area66.8 Ų
Heavy Atom Count23
Formal Charge0
Complexity256
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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