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1-Monopalmitin

CAT: 0804-HY-W009141-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W009141-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
1-Monopalmitin (Glyceryl palmitate) is an activator of the PI3K/Akt pathway and an inhibitor of P-glycoprotein (P-gp) . 1-Monopalmitin can induce G2/M arrest and caspase-dependent apoptosis in cancer cells, while inhibiting IAPs protein expression. 1-Monopalmitin can increase drug accumulation by inhibiting P-gp activity in intestinal Caco-2 cells. 1-Monopalmitin has the ability to induce protective autophagy and apoptosis of lung cancer cells (IC50=50-58 μg/mL), with low toxicity to normal cells[1][2].
CAS Number
542-44-9
Product Name Alternative
Glyceryl palmitate
UNSPSC
12352211
Hazard Statement
H302
Target
Akt; Apoptosis; Caspase; IAP; P-glycoprotein; PI3K
Type
Natural Products
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel; PI3K/Akt/mTOR
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/1-monopalmitin.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 50 mg/mL (warming; heat to 60°C)
Smiles
OC(CO)COC(CCCCCCCCCCCCCCC)=O
Molecular Formula
C19H38O4
Molecular Weight
330.51
Precautions
H302
References & Citations
[1]Niu L, et al. 1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/A kt pathway in vitro. Environmental Toxicology, 2023, 38 (11) : 2621-2631.|[2]Tomoko Konishi, et al. A bitter melon extract inhibits the P-glycoprotein activity in intestinal Caco-2 cells: monoglyceride as an active compound. Biofactors. 2004;22 (1-4) :71-4.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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