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NVS-ZP7-4

CAT: 0804-HY-114395-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114395-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NVS-ZP7-4 is an inhibitor of the zinc transporter SLC39A7 (ZIP7) and indicates ER zinc levels. ZIP7 is an active molecular node in the Notch pathway and mediates ferroptosis. NVS-ZP7-4 induces ER stress and exerts a certain ferroptosis-inhibiting effect, reduces Erastin -induced cell death[1][2].
CAS Number
2349367-89-9
UNSPSC
12352005
Target
Ferroptosis; SLC39 (Zinc Transporter)
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/NVS-ZP7-4.html
Purity
98.85
Solubility
DMSO : ≥ 125 mg/mL
Smiles
O=C(NC12CCN(C[C@@H](NC3=NC4=CC=C(F)C=C4S3)CC5=CC=CC=C5)CC2)NC6=C1C=CC=C6
Molecular Formula
C28H28FN5OS
Molecular Weight
501.62
References & Citations
[1]Nolin E, et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen. Nat Chem Biol. 2019 Feb;15 (2) :179-188.|[2]Chen PH, et al. Zinc transporter ZIP7 is a novel determinant of ferroptosis. Cell Death Dis. 2021 Feb 19;12 (2) :198.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Nvs-ZP7-4
CAS Number2349367-89-9
PubChem CID134823928
IUPAC Name1'-[(2S)-2-[(6-fluoro-1,3-benzothiazol-2-yl)amino]-3-phenylpropyl]spiro[1,3-dihydroquinazoline-4,4'-piperidine]-2-one
Molecular FormulaC28H28FN5OS
Molecular Weight501.6
XLogP5.5
Topological Polar Surface Area97.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity758
SMILES
C1CN(CCC12C3=CC=CC=C3NC(=O)N2)C[C@H](CC4=CC=CC=C4)NC5=NC6=C(S5)C=C(C=C6)F
InChI
InChI=1S/C28H28FN5OS/c29-20-10-11-24-25(17-20)36-27(32-24)30-21(16-19-6-2-1-3-7-19)18-34-14-12-28(13-15-34)22-8-4-5-9-23(22)31-26(35)33-28/h1-11,17,21H,12-16,18H2,(H,30,32)(H2,31,33,35)/t21-/m0/s1
InChIKey
FZOFDZMKSAUTHT-NRFANRHFSA-N
Chemical Structure
2D Structure
2D structure of Nvs-ZP7-4
CAS: 2349367-89-9
CID: 134823928
Formula: C28H28FN5OS
MW: 501.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight501.6
XLogP35.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count6
Exact Mass501.19985987
Monoisotopic Mass501.19985987
Topological Polar Surface Area97.5 Ų
Heavy Atom Count36
Formal Charge0
Complexity758
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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