Cadmium pyrithione
CAT:
804-HY-164689
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Cadmium pyrithione
- CAS Number: 18897-36-4
- UNSPSC Description: Cadmium pyrithione is a metal compound that inhibits protein deubiquitinase activity. Cadmium pyrithione treatment results in significant accumulation of ubiquitinated proteins in cancer cells and primary leukemia cells. Cadmium pyrithione strongly inhibits the activity of proteasome deubiquitinase (such as USP14 and UCHL5), but has a smaller inhibitory effect on 20S proteasome activity. The anticancer activity of Cadmium pyrithione is associated with the induction of apoptosis through caspase activation. Furthermore, Cadmium pyrithione inhibition inhibited proteasome function and suppressed tumor growth in animal xenograft models[1].
- Target Antigen: Proteasome
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/cadmium-pyrithione.html
- Smiles: N12[O-][Cd+2]3([O-]N4C=CC=CC4=[S]3)[S]=C1C=CC=C2
- Molecular Weight: 364.72
- References & Citations: [1]Cadmium pyrithione suppresses tumor growth in vitro and in vivo through inhibition of proteasomal deubiquitinase
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported