Zinc Pyrithione

• UNSPSC Description:

  Zinc Pyrithione is an antifungal and antibacterial agent disrupting membrane transport by blocking the proton pump[1]. Zinc Pyrithione is also a copper ionophore that delivers copper into cells and is a useful tool for studying cuproptosis[2].

• Target Antigen:

  Bacterial; Cuproptosis; Fungal; Proton Pump

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;Apoptosis;Membrane Transporter/Ion Channel

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/zinc-pyrithione.html

• Purity:

  99.49

• Solubility:

  DMSO : 33.33 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL

• Smiles:

  N12[O-][Zn+2]3([S]=C1C=CC=C2)[O-]N(C=CC=C4)C4=[S]3

• Molecular Weight:

  317.69

• References & Citations:

  [1]Ermolayeva, E. and D. Sanders, Mechanism of pyrithione-induced membrane depolarization in Neurospora crassa. Appl Environ Microbiol, 1995. 61(9): p. 3385-90.|[2]Peter Tsvetkov, et al. Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022 Mar 18;375(6586):1254-1261.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  13463-41-7