Caspase-1 + p10 + p12 Recombinant Rabbit Monoclonal Antibody [JE56-35]

Caspase-1 + p10 + p12 Recombinant Rabbit Monoclonal Antibody [JE56-35]

• Description: Caspase-1/Interleukin-1 converting enzyme (ICE) is an evolutionarily conserved enzyme that proteolytically cleaves other proteins, such as the precursors of the inflammatory cytokines interleukin 1β and interleukin 18 as well as the pyroptosis inducer Gasdermin D, into active mature peptides. It plays a central role in cell immunity as an inflammatory response initiator. Once activated through formation of an inflammasome complex, it initiates a proinflammatory response through the cleavage and thus activation of the two inflammatory cytokines, interleukin 1β (IL-1β) and interleukin 18 (IL-18) as well as pyroptosis, a programmed lytic cell death pathway, through cleavage of Gasdermin D. The two inflammatory cytokines activated by Caspase-1 are excreted from the cell to further induce the inflammatory response in neighboring cells.
• Product Name Alternative: CASP1 antibody Caspase 1 apoptosis related cysteine peptidase antibody ICE antibody IL 1 beta converting enzyme antibody IL 1BC antibody IL1B convertase antibody Interleukin 1 beta convertase antibody Interleukin 1 beta converting enzyme antibody p45 antibody
• Abbreviation: CASP1, IL1BC, IL1BCE
• CAS Number: 9000-83-3
• Swiss Prot: P29466 Human, P29452 Mouse, P43527 Rat
• Cellular Locus: Cytoplasm, Cell membrane.
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant protein within Human Caspase-1 aa 255-404 / 404.
• Isotype: IgG
• Clone: JE56-35
• Conjugation: Non-conjugated
• Type: Recombinant Rabbit monoclonal Antibody
• Applications: WB, IF-Cell, IHC-P
• Positive Control: Raji cell lysate, THP-1 cell lysate, U-937 cell lysate, HepG2 cell lysate, RAW264.7 cell lysate, mouse spleen tissue lysate, rat spleen tissue lysate, THP-1, RAW264.7, human spleen tissue, mouse spleen tissue, rat spleen tissue.
• Concentration: 1 mg/mL
• Dilution: WB: 1:2,000 ;IF-Cell: 1:100 ;IHC-P: 1:500-1:2,000
• Purity: Protein A affinity purified.
• Form: Liquid
• Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
• Molecular Weight: Predicted band size: 45/42/35/12/10 kDa
• Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
• Recombinant Antibody: Yes