NED-3238

• Description:

  NED-3238 is a highly potent arginase I and II inhibitor with IC50 values of 1.3 nM and 8.1 nM, respectively[1].

• UNSPSC:

  12352005

• Target:

  Arginase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation; Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ned-3238.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@]1(N)CN(C[C@@H](N)CC2=CC=CC=C2)C[C@@H]1CCCB(O)O)O

• Molecular Formula:

  C17H28BN3O4

• Molecular Weight:

  349.23

• References & Citations:

  [1]Van Zandt MC, et al. Discovery of N-Substituted 3-Amino-4- (3-boronopropyl) pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II. J Med Chem. 2019 Aug 23.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2389062-09-1