Ned-K

• Description :

  Ned-K is a nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Ned-K is effective at dampening simulated ischaemia and reperfusion (sIR) -induced Ca2+ oscillations in cardiomyocytes[1].

• UNSPSC :

  12352005

• Target :

  Calcium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/ned-k.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@H]1N[C@@H](C2=C(C1)C3=C(N2)C=CC=C3)C4=CC=C(C(CN5CCN(CC5)C6=CC=CC=C6C#N)=C4)OC)O

• Molecular Formula :

  C31H31N5O3

• Molecular Weight :

  521.61

• References & Citations :

  [1]Sean M Davidson, et al. Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore. Cardiovasc Res. 2015 Dec 1;108 (3) :357-66.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2250019-90-8]