Retro-2 cycl

• Description :

  Retro-2 cycl (RN 1-001) is a retrograde transport inhibitor with antiviral activity. Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudoviruses, with an IC50 of 54 μM and 160 μM respectively[1][2][3].

• Product Name Alternative :

  RN 1-001

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Arenavirus; HPV; Virus Protease

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/Retro-2_cycl.html

• Concentration :

  10mM

• Purity :

  99.17

• Solubility :

  DMSO : ≥ 125 mg/mL

• Smiles :

  O=C1C2=CC=CC=C2NC(N1C3=CC=CC=C3)C4=CC=C(S4)C

• Molecular Formula :

  C19H16N2OS

• Molecular Weight :

  320.41

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Carney DW, et al. Structural optimization of a retrograde trafficking inhibitor that protects cells from infections by human polyoma- and papillomaviruses. Bioorg Med Chem. 2014 Sep 1;22 (17) :4836-47.|[2]Wen Dai, et al. Antiviral Effect of Retro-2.1 against Herpes Simplex Virus Type 2 In Vitro. J Microbiol Biotechnol. 2018 Jun 28;28 (6) :849-859.|[3]Wenwen Dai, et al. Antiviral effects of Retro-2cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo. Antiviral Res. 2017 Aug:144:311-321.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1429192-00-6]