RETRA

• UNSPSC Description:

  RETRA is a mutant p53-dependent activator of p73 that suppresses mutant p53-bearing cancer cells. RETRA increases the expression level of p73, and a release of p73 from the blocking complex with mutant p53, which produces tumor-suppressor effects[1].

• Target Antigen:

  MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/retra.html

• Purity:

  99.42

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  OC1=CC=C(C(CSC2=NCCS2)=O)C=C1O

• Molecular Weight:

  269.34

• References & Citations:

  [1]J E Kravchenko, et al. Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc Natl Acad Sci U S A. 2008 Apr 29;105(17):6302-7.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  1036069-26-7