Retro-1

• Description :

  Retro-1 is a toxin inhibitor. Retro-1 blocks the retrograde transport of STxB to the trans-Golgi network/Golgi. Retro-1 inhibits the cytotoxic effects of Ricin, bacterial toxins Stx1 and Stx2. Retro-1 can also substantially enhance the effectiveness of antisense and splice switching oligonucleotides[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Related Pathways :

  Anti-infection

• Field of Research :

  Infection

• Smiles :

  O=C1NC2=CC=C(C=C2C(N(C1)C(CC)=O)C3=CC=CC=C3)Br

• Molecular Formula :

  C18H17BrN2O2

• Molecular Weight :

  373.24

• References & Citations :

  [1]Stechmann B, et al. Inhibition of retrograde transport protects mice from lethal ricin challenge. Cell. 2010 Apr 16;141 (2) :231-42. |[2]Ming X, et al. The small molecule Retro-1 enhances the pharmacological actions of antisense and splice switching oligonucleotides. Nucleic Acids Res. 2013 Apr 1;41 (6) :3673-87.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [313683-81-7]