(R) -eIF4A3-IN-2

• Description:

  (R) -eIF4A3-IN-2 is a less active enantiomer of eIF4A3-IN-2. eIF4A3-IN-2 is a highly selective and noncompetitive eukaryotic initiation factor 4A-3 (eIF4A3) inhibitor with an IC50 of 110 nM[1].

• UNSPSC:

  12352005

• Target:

  Eukaryotic Initiation Factor (eIF)

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/r-eif4a3-in-2.html

• Purity:

  95.0

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C(N1C[C@@H](C2=CC=C(Cl)C=C2)N(C(C3=CC=C(Br)C=C3)=O)CC1)C4=C5C=CC(Br)=CN5N=C4

• Molecular Formula:

  C25H19Br2ClN4O2

• Molecular Weight:

  602.70

• References & Citations:

  [1]Iwatani-Yoshihara M, et al. Discovery and Characterization of a Eukaryotic Initiation Factor 4A-3-Selective Inhibitor That Suppresses Nonsense-Mediated mRNA Decay. ACS Chem Biol. 2017;12 (7) :1760-1768.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EIF4

• CAS Number:

  [2095484-82-3]