Cidofovir (sodium)

CAT: 0804-HY-167911Size: 1 EachDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-167911Size:1 Each

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

Cidofovir sodium is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir sodium inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir sodium induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer[1][3]. Cidofovir sodium also has anti-orthopoxvirus and anti-variola activities[4].

CAS Number

127749-27-3

Product Name Alternative

GS 0504 (sodium) ; HPMPC (sodium) ; (S) -HPMPC (sodium)

UNSPSC

12352005

Target

Apoptosis; CMV; DNA/RNA Synthesis; Endogenous Metabolite; Orthopoxvirus

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

Field of Research

Infection; Cancer

Assay Protocol

https://www.medchemexpress.com/cidofovir-sodium.html

Smiles

OC[C@@H](OCP(O[Na])(O[Na])=O)CN1C=CC(N)=NC1=O

Molecular Formula

C8H12N3Na2O6P

Molecular Weight

323.15

References & Citations

[1]David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65 (4) :399-403.|[2] M Bray, et al. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge. J Infect Dis. 2000 Jan;181 (1) :10-9.|[3]Simona Catalani, et al. Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir. Toxicol In Vitro. 2017 Jun;41:49-55.|[4]Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57 (1-2) :13-23.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 4

Chemical Information

Cidofovir Sodium

CAS Number	127749-27-3
PubChem CID	135406
IUPAC Name	disodium;4-amino-1-[(2S)-3-hydroxy-2-(phosphonatomethoxy)propyl]pyrimidin-2-one
Molecular Formula	C8H12N3Na2O6P
Molecular Weight	323.15
Topological Polar Surface Area	151
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Heavy Atom Count	20
Formal Charge	0
Complexity	406

SMILES

C1=CN(C(=O)N=C1N)C[C@@H](CO)OCP(=O)([O-])[O-].[Na+].[Na+]

InChI

InChI=1S/C8H14N3O6P.2Na/c9-7-1-2-11(8(13)10-7)3-6(4-12)17-5-18(14,15)16;;/h1-2,6,12H,3-5H2,(H2,9,10,13)(H2,14,15,16);;/q;2*+1/p-2/t6-;;/m0../s1

InChIKey

HKIAHFPOQYDOHP-ILKKLZGPSA-L

Chemical Structure

2D Structure

CAS: 127749-27-3

CID: 135406

Formula: C8H12N3Na2O6P

MW: 323.15

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	323.15
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	5
Exact Mass	323.02591067
Monoisotopic Mass	323.02591067
Topological Polar Surface Area	151 Å²
Heavy Atom Count	20
Formal Charge	0
Complexity	406
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	3
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-17438-01	Cidofovir
HY-17438A-01	Cidofovir (dihydrate)
HY-131606	Cidofovir diphosphate
HY-17438R-01	Cidofovir (Standard)
HY-131606S	Cidofovir diphosphate-13C3
HY-131606B-01	Cidofovir diphosphate tri (triethylamine)
HY-Y1310-01	Sodium alginate
HY-16504-01	Treprostinil (sodium)
HY-B0656A-01	Rabeprazole (sodium)
HY-101705-01	Tibenelast sodium

Alternative Products

Catalog	Name
T71066-01	Cidofovir sodium
317525	Cidofovir
B1238-25	Cidofovir dihydrate
269625-01	Cidofovir, anhydrous

Cidofovir (sodium)

Chemical Information

Related Products

Alternative Products

Popular Products