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Cidofovir

CAT: 0804-HY-17438-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17438-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cidofovir (GS 0504) is an acyclic monophosphate nucleotide analogue and CMV inhibitor with antiviral activity. Cidofovir inhibits cytomegalovirus (CMV) replication by selectively inhibiting viral DNA polymerase. Cidofovir induces apoptosis and can be used in studies of AIDS cytomegalovirus retinitis, herpes, and cancer[1][3]. Cidofovir also has anti-orthopoxvirus and anti-variola activities[4].
CAS Number
113852-37-2
Product Name Alternative
GS 0504; HPMPC; (S) -HPMPC
UNSPSC
12352005
Hazard Statement
H301, H315
Target
Apoptosis; CMV; DNA/RNA Synthesis; Endogenous Metabolite; Orthopoxvirus
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Cidofovir.html
Purity
99.95
Solubility
DMSO : < 1 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 3.33 mg/mL (ultrasonic)
Smiles
OC[C@@H](OCP(O)(O)=O)CN1C=CC(N)=NC1=O
Molecular Formula
C8H14N3O6P
Molecular Weight
279.19
Precautions
H301, H315
References & Citations
[1]David J Maggs, et al. In vitro efficacy of ganciclovir, cidofovir, penciclovir, foscarnet, idoxuridine, and acyclovir against feline herpesvirus type-1. Am J Vet Res. 2004 Apr;65 (4) :399-403.|[2] M Bray, et al. Cidofovir protects mice against lethal aerosol or intranasal cowpox virus challenge. J Infect Dis. 2000 Jan;181 (1) :10-9.|[3]Simona Catalani, et al. Reduced cell viability and apoptosis induction in human thyroid carcinoma and mesothelioma cells exposed to cidofovir. Toxicol In Vitro. 2017 Jun;41:49-55.|[4]Robert O Baker, et al. Potential antiviral therapeutics for smallpox, monkeypox and other orthopoxvirus infections. Antiviral Res. 2003 Jan;57 (1-2) :13-23.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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