CFL-137

• Description:

  CFL-137 is a potent KRasG12C inhibitor. CFL-137 shows an antiproliferative effect. CFL-137 shows anticancer activity. CFL-137 has the potential for the research of lung cancer[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H410

• Target:

  Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cfl-137.html

• Purity:

  99.92

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=CC1=C2C=CC=CC2=CC=C1O

• Molecular Formula:

  C11H8O2

• Molecular Weight:

  172.18

• Precautions:

  H410

• References & Citations:

  [1]Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  K-Ras

• CAS Number:

  708-06-5