CFL-120

CAT: 0804-HY-W041315-01Size: 1 gDry Ice: NoHazardous: No
CAT#:0804-HY-W041315-01Size:1 g
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].
CAS Number
[18711-15-4]
UNSPSC
12352005
Hazard Statement
H301, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cfl-120.html
Purity
98.24
Solubility
10 mM in DMSO
Smiles
C1=C(C=C(C2=C1NC(C2=O)=O)Cl)Cl
Molecular Formula
C8H3Cl2NO2
Molecular Weight
216.02
Precautions
H301, H315, H319, H335
References & Citations
[1]Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

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