CFL-120

• Description :

  CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H315, H319, H335

• Target :

  Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cfl-120.html

• Purity :

  98.24

• Solubility :

  10 mM in DMSO

• Smiles :

  C1=C(C=C(C2=C1NC(C2=O)=O)Cl)Cl

• Molecular Formula :

  C8H3Cl2NO2

• Molecular Weight :

  216.02

• Precautions :

  H301, H315, H319, H335

• References & Citations :

  [1]Orgován Z, et al. Covalent fragment mapping of KRasG12C revealed novel chemotypes with in vivo potency. Eur J Med Chem. 2023 Mar 15;250:115212.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  K-Ras

• CAS Number :

  [18711-15-4]