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Antifungal agent 137

CAT: 0804-HY-178340Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178340Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Antifungal agent 137 (Compound 4S) is an antifungal agent. Antifungal agent 137 inhibits Phomopsis sp. (PS), with an EC50 of 0.15 μg/mL. Antifungal agent 137 inhibits lanosterol 14α-demethylase (CYP51), with an IC50 of 5.00 μg/mL. Antifungal agent 137 disrupts the morphology of PS mycelia, impairs cell membrane integrity, and induces an increase in intracellular ROS levels, triggering oxidative stress. Antifungal agent 137 can be used for the study of fungal infection[1].
CAS Number
3032062-22-6
UNSPSC
12352005
Target
Cytochrome P450; Fungal; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection
Smiles
OC(CN1N=CN=C1)(C2=CC=C(F)C=C2F)CN3CCN(S(=O)(C4=CC(F)=CC=C4F)=O)CC3
Molecular Formula
C21H21F4N5O3S
Molecular Weight
499.48
References & Citations
[1]Wu W, et al. Novel 1,2,4-Triazole Derivatives Containing a Benzenesulfonamide Moiety as Potential Antifungal Agents for Controlling Postharvest Soft Rot in Kiwifruit. J Agric Food Chem. 2025 Oct 1;73 (39) :24549-24560.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP51

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