FL-411

• Description :

  FL-411 is a potent and selective BRD4 inhibitor with an IC50 of 0.43±0.09 μM for BRD4 (1) .

• Product Name Alternative :

  BRD4-IN-1

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Epigenetic Reader Domain

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/FL-411.html

• Purity :

  99.05

• Solubility :

  DMSO : 5.4 mg/mL (ultrasonic)

• Smiles :

  CN1CCC2=C(SC(N=C(C3=CC(C)=C(O)C(C)=C3)N4)=C2C4=O)C1

• Molecular Formula :

  C18H19N3O2S

• Molecular Weight :

  341.43

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Ouyang L, et al. Discovery of a Small-Molecule Bromodomain-Containing Protein 4 (BRD4) Inhibitor That InducesAMP-Activated Protein Kinase-Modulated Autophagy-Associated Cell Death in Breast Cancer. J Med Chem. 2017 Dec 28;60 (24) :9990-10012.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  BRD4

• CAS Number :

  [2118944-88-8]