PARPi-FL

CAT: 0804-HY-120115-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-120115-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PARPi-FL (Olaparib-bodipy FL) is a small-molecule fluorescent inhibitor of PARP1 that can specifically bind to PARP1. PARPi-FL can be used as a fluorescent imaging agent for tumor detection, diagnosis, and surgical guidance[1][2][3].
CAS Number
[1380359-84-1]
Product Name Alternative
Olaparib-bodipy FL
UNSPSC
12171500
Target
Fluorescent Dye; PARP
Type
Dye Reagents
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parpi-fl.html
Purity
99.74
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N]6[B+3]([F-])([N-]54)[F-])=O)=O)=C2)F)C7=C1C=CC=C7
Molecular Formula
C34H32BF3N6O3
Molecular Weight
640.46
References & Citations
[1]Ziadeh T, et al. Poly (ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22 (18) :1237-1250.|[2]Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16 (5) :432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23.|[3]Susanne Kossatz, et al.Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Sci Rep. 2016; 6: 21371.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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