PARPi-FL

• Product Name Alternative:

  Olaparib-bodipy FL

• UNSPSC Description:

  PARPi-FL is a small molecule and fluorescent inhibitor of PARP1. PARPi-FL is a highly selective probe and can be used as an imaging agent to detect glioblastomas in vivo. (Excitation/Emission max 507/525 nm)[1][3].

• Target Antigen:

  Fluorescent Dye; PARP

• Type:

  Dye Reagents

• Related Pathways:

  Cell Cycle/DNA Damage;Epigenetics;Others

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/parpi-fl.html

• Purity:

  99.74

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C1NN=C(CC2=CC=C(C(C(N3CCN(CC3)C(CCC4=CC=C5C=C6C(C)=CC(C)=[N]6[B+3]([F-])([N-]54)[F-])=O)=O)=C2)F)C7=C1C=CC=C7

• Molecular Weight:

  640.46

• References & Citations:

  [1]Ziadeh T, et al. Poly(ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22(18):1237-1250.|[2]Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16(5):432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23.|[3]Susanne Kossatz, et al.Detection and delineation of oral cancer with a PARP1 targeted optical imaging agent. Sci Rep. 2016; 6: 21371.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  1380359-84-1