[Ala17]-MCH

• UNSPSC Description:

  [Ala17]-MCH, a MCH analogue (HY-P1525A), is a selective ligand for MCHR1 (Ki=0.16 nM) over MCHR2 (Ki=34 nM). [Eu3+ chelate-labeled [Ala17]-MCH shows high affnity for MCHR1 (Kd=0.37 nM) while has little demonstrable binding affnity for MCHR2[1].

• Target Antigen:

  MCHR1 (GPR24)

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/ala17-mch.html

• Purity:

  98.28

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  O=C1N2C(CCC2)([H])C(N[C@@H](CSSC[C@@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCCNC(N)=N)=O)CC3=CC=C(C=C3)O)=O)C(C)C)=O)CCCNC(N)=N)=O)=O)CC(C)C)=O)CCSC)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@H](CCSC)NC([C@H](CC(O)=O)NC([C@@H](NC([C@@H](N)CC(O)=O)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)C(N[C@@H](C)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O

• Molecular Weight:

  2271.71

• References & Citations:

  [1]Xiaoying Gao, et al. Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2. Anal Biochem. 2004 May 15;328(2):187-95.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  359784-84-2