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Erinacine C

CAT: 0804-HY-N11004Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N11004Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Erinacine C is the inhibitor for NF-κB signaling pathway and the activator for Nrf2 signaling pathway. Erinacine C exhibits antioxidant, neuroprotective and anti-inflammatory effects[1][2].
CAS Number
156101-09-6
UNSPSC
12352005
Target
Heme Oxygenase (HO) ; Keap1-Nrf2; NF-κB
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; NF-κB
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/erinacine-c.html
Purity
98.61
Solubility
Ethanol : 10 mg/mL (ultrasonic; warming)
Smiles
C[C@]12C([C@]3([H])[C@]([C@]4([H])[C@@](O[C@@]5([H])[C@](OC[C@H]([C@@H]5O)O)([H])O4)([H])C(CO)=CC3)(CC1)C)=C(CC2)C(C)C
Molecular Formula
C25H38O6
Molecular Weight
434.57
References & Citations
[1]Hiromichi Kenmoku, et al. Erinacine Q, a new erinacine from Hericium erinaceum, and its biosynthetic route to erinacine C in the basidiomycete. Biosci Biotechnol Biochem. 2002 Mar;66 (3) :571-5. |[2]Wang LY, et al., Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS. Molecules. 2019 Sep 12;24 (18) :3317.|[3]Lee KF, et al., The Cerebral Protective Effect of Novel Erinacines from Hericium erinaceus Mycelium on In Vivo Mild Traumatic Brain Injury Animal Model and Primary Mixed Glial Cells via Nrf2-Dependent Pathways. Antioxidants (Basel) . 2024 Mar 19;13 (3) :371.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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