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(+) -Erinacin A

CAT: 0804-HY-111954Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-111954Size:1 mg
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Description
(+) -Erinacin A (Erinacine A) is a cyanoditerpenoid isolated from Hericium erinaceus with anticancer, anti-inflammatory and neuroprotective activities. (+) -Erinacin A can induce cancer cell death by activating extrinsic and intrinsic apoptosis pathways. (+) -Erinacin A can also inhibit the expression of NO synthase (iNOS) and the production of nitrotyrosine to exert inflammatory and neuroprotective effects, thereby reducing ischemic brain damage[1][2][3][4][5].
CAS Number
156101-08-5
Product Name Alternative
Erinacine A
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; Histone Acetyltransferase; JNK; NF-κB; NO Synthase; p38 MAPK
Type
Reference compound
Related Pathways
Apoptosis; Epigenetics; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/plus-erinacin-a.html
Purity
99.97
Solubility
Ethanol : 10 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@@H]2[C@@](CC[C@]3(C)C4=C(C(C)C)CC3)(C)C4=CC=C(C=O)C2)OC1
Molecular Formula
C25H36O6
Molecular Weight
432.55
References & Citations
[1]Bailly C, et.al. Erinacine A and related cyathane diterpenoids: Molecular diversity and mechanisms underlying their neuroprotection and anticancer activities. Pharmacol Res. 2020 Sep;159:104953.|[2]Tsai-Teng T, et al. Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer’s disease-related pathologies in APPswe/PS1dE9 transgenic mice[J]. Journal of biomedical science, 2016, 23: 1-12.|[3]Prasher P, et al. Key oncologic pathways inhibited by Erinacine A: a perspective for its development as an anticancer molecule[J]. Biomedicine & Pharmacotherapy, 2023, 160: 114332.|[4]Lee K F, et al. Protective effects of Hericium erinaceus mycelium and its isolated erinacine A against ischemia-injury-induced neuronal cell death via the inhibition of iNOS/p38 MAPK and nitrotyrosine[J]. International journal of molecular sciences, 2014, 15 (9) : 15073-15089.|[5]Lee K C, et al. Induction apoptosis of erinacine A in human colorectal cancer cells involving the expression of TNFR, Fas, and Fas ligand via the JNK/p300/p50 signaling pathway with histone acetylation[J]. Frontiers in Pharmacology, 2019, 10: 1174.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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