W146 (Standard)

• Description :

  W146 (Standard) is the analytical standard of W146 (HY-101395) . This product is intended for research and analytical applications. W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

• CAS Number :

  [909725-61-7]

• Target :

  Apoptosis; LPL Receptor; Reference Standards

• Related Pathways :

  Apoptosis; GPCR/G Protein; Others

• Field of Research :

  Cancer; Metabolic Disease

• Smiles :

  O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O

• Molecular Formula :

  C16H27N2O4P

• Molecular Weight :

  342.37

• References & Citations :

  [1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2 (8) :434-41. Epub 2006 Jul 9.|[2]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.|[3]Jingjing Liu, et al. 3-amino-4- (3-hexylphenylamino) -4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1 (4) : 197–203.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards