W146 (Standard)

• Description:

  W146 (Standard) is the analytical standard of W146 (HY-101395) . This product is intended for research and analytical applications. W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

• Target:

  Apoptosis; LPL Receptor; Reference Standards

• Related Pathways:

  Apoptosis; GPCR/G Protein; Others

• Field of Research:

  Cancer; Metabolic Disease

• Smiles:

  O=C (NC1=CC=CC (CCCCCC) =C1) [C@H] (N) CCP (O) (O) =O

• Molecular Formula:

  C16H27N2O4P

• Molecular Weight:

  342.37

• References & Citations:

  [1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2 (8) :434-41. Epub 2006 Jul 9.|[2]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.|[3]Jingjing Liu, et al. 3-amino-4- (3-hexylphenylamino) -4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1 (4) : 197–203.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference Standards

• CAS Number:

  909725-61-7