W146

• Description :

  W146 is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Apoptosis; LPL Receptor

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; GPCR/G Protein

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Cancer; Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/W146.html

• Purity :

  99.83

• Solubility :

  DMSO : 22.22 mg/mL (ultrasonic; adjust pH to 3 with TFA)

• Smiles :

  O=C(NC1=CC=CC(CCCCCC)=C1)[C@H](N)CCP(O)(O)=O

• Molecular Formula :

  C16H27N2O4P

• Molecular Weight :

  342.37

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]M Germana Sanna, et al. Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo. Nat Chem Biol. 2006 Aug;2 (8) :434-41. Epub 2006 Jul 9.|[2]Hang Wang, et al. Sphingosine-1-phosphate promotes the proliferation and attenuates apoptosis of Endothelial progenitor cells via S1PR1/S1PR3/PI3K/Akt pathway. Cell Biol Int. 2018 May 23.|[3]Jingjing Liu, et al. 3-amino-4- (3-hexylphenylamino) -4-oxobutyl phosphonic acid (W146), a Selective Antagonist of Sphingosine-1-phospahte Receptor Subtype 1, Enhances AMD3100-stimulated Mobilization of Hematopoietic Stem Progenitor Cells in Animals. J Biochem Pharmacol Res. 2013 Dec; 1 (4) : 197–203.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Citation 01 :

  Cancer Commun (Lond) . 2025 Jul 16.|iScience. 2024 Oct 30;27 (12) :111290.|J Nutr Biochem. 2024 Apr:126:109587.|Nat Cell Biol. 2025 Jun;27 (6) :918-930.|Autophagy. 2025 Apr 10:1-19.

• CAS Number :

  [909725-61-7]