Ac-Ile-Glu-Thr-Asp-pNA

Ac-Ile-Glu-Thr-Asp-pNA

• CAS Number: 219138-21-3
• UNSPSC Description: Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity[1].
• Target Antigen: Caspase
• Type: Peptides
• Related Pathways: Apoptosis
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/ac-ile-glu-thr-asp-pna.html
• Purity: 99.90
• Solubility: H2O : 0.98 mg/mL (adjust pH to 12 with 1 M NaOH)
• Smiles: O=C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(NC1=CC=C([N+]([O-])=O)C=C1)=O)=O)[C@H](CCC(O)=O)NC([C@@H](NC(C)=O)[C@@H](C)CC)=O
• Molecular Weight: 638.62
• References & Citations: [1]Smith GK, et al. Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition. Arch Biochem Biophys. 2002;399(2):195-205.
• Shipping Conditions: Blue Ice
• Storage Conditions: -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported