Ac-Trp-Glu-His-Asp-Aldehyde

• UNSPSC Description:

  Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].

• Target Antigen:

  Caspase

• Type:

  Peptides

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ac-trp-glu-his-asp-aldehyde.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC(C[C@@H](C=O)NC([C@H](CC1=CN=CN1)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O

• Molecular Weight:

  611.60

• References & Citations:

  [1]Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. |[2]Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  189275-71-6