Ac-Trp-Glu-His-Asp-Aldehyde

CAT:

804-HY-P4535

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CAS Number: 189275-71-6
UNSPSC Description: Ac-Trp-Glu-His-Asp-Aldehyde is a potent and selective caspase-1 inhibitor with a Ki value of 56 pM[1][2].
Target Antigen: Caspase
Type: Peptides
Related Pathways: Apoptosis
Applications: COVID-19-immunoregulation
Field of Research: Inflammation/Immunology
Assay Protocol: https://www.medchemexpress.com/ac-trp-glu-his-asp-aldehyde.html
Solubility: 10 mM in DMSO
Smiles: OC(C[C@@H](C=O)NC([C@H](CC1=CN=CN1)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O
Molecular Weight: 611.60
References & Citations: [1]Kindermann M, et al. Selective and sensitive monitoring of caspase-1 activity by a novel bioluminescent activity-based probe. Chem Biol. 2010 Sep 24;17(9):999-1007. |[2]Rano TA, et al. A combinatorial approach for determining protease specificities: application to interleukin-1beta converting enzyme (ICE). Chem Biol. 1997 Feb;4(2):149-55.
Shipping Conditions: Room temperature
Clinical Information: No Development Reported

Cat	Name
HY-P4535	Ac-Trp-Glu-His-Asp-Aldehyde
HY-P4547	Ac-Trp-Glu-His-Asp-AMC
HY-W338079	Ac-Asp-Glu-Val-Asp-pNA
HY-120833-02	Ac-Ile-Glu-Thr-Asp-pNA
HY-120833-01	Ac-Ile-Glu-Thr-Asp-pNA
HY-P3761-01	Ac-Tyr-Val-Lys-Asp-aldehyde
HY-P3761-02	Ac-Tyr-Val-Lys-Asp-aldehyde
HY-P5510	Ac-Asp-Glu-Asp(EDANS)-Glu-Glu-Abu-ψ-(COO)Ala-Ser-Lys(DABCYL)-NH2
HY-128487-02	H-Trp-Glu-OH
HY-128487-01	H-Trp-Glu-OH

Cat	Name
3187-v	Ac-Trp-Glu-His-Asp-H (aldehyde)
4027878.0005	Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)
N-1630.0005	Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)
4027878.0025	Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)
N-1630.0025	Ac-Trp-Glu-His-Asp-aldehyde (pseudo acid)
3186-v	Ac-Trp-Glu-His-Asp-MCA
MBS406194-02	Ac-Trp-Glu-His-Asp-H
MBS406421-02	Ac-Trp-Glu-His-Asp-MCA
I-1715.0005	Ac-Trp-Glu-His-Asp-AMC
I-1715.0025	Ac-Trp-Glu-His-Asp-AMC