Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (TFA)

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH (TFA)

• UNSPSC Description: Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].
• Target Antigen: Src
• Type: Peptides
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ac-tyr-po3h2-glu-glu-ile-glu-oh-tfa.html
• Solubility: H2O
• Smiles: O=C(O)CC[C@@H](C(O)=O)NC([C@H]([C@@H](C)CC)NC([C@H](CCC(O)=O)NC([C@H](CCC(O)=O)NC([C@H](CC1=CC=C(OP(O)(O)=O)C=C1)NC(C)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
• Molecular Weight: 917.73
• References & Citations: [1]G J Pacofsky, et al. Potent dipeptide inhibitors of the pp60c-src SH2 domain. J Med Chem. 1998 May 21;41(11):1894-908.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported