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FBXW5 rabbit pAb

CAT: 0855-ES16497-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008]
Description
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented. [provided by RefSeq, Jul 2008],
Product Name Alternative
F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
UniProt
Q969U6
Swiss Prot
Q969U6
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from human FBXW5 AA range: 319-369
Target
FBXW5
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Concentration
1 mg/ml
Dilution
WB 1:500-2000
Buffer
-20°C/1 year
Molecular Weight
60kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
60kD
Fragment
IgG
Subcellular Location
Cytoplasm .
Other Product Names
F-box/WD repeat-containing protein 5 (F-box and WD-40 domain-containing protein 5)
Gene ID (Human)
54461

UniProtKB · Q969U6

F-box/WD repeat-containing protein 5

FBXW5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q969U6
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FBXW5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2RDZ6, Q59ET5, Q5SPZ8, Q5SPZ9, Q5SQ00, Q5SQ02, Q5SQ03, Q5SQ04, Q8WY79, Q96GJ6, Q9BSU8, Q9H6A8, Q9HBQ6, Q9NSZ3
Protein keywords

Coding sequence diversity

Alternative splicing

Cellular component

Cytoplasm

PTM

PhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

Domain

RepeatWD repeat

Biological process

Ubl conjugation pathway