Coptisine

Coptisine

• CAS Number: 3486-66-6
• UNSPSC Description: Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.
• Target Antigen: Indoleamine 2,3-Dioxygenase (IDO)
• Type: Natural Products
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Cancer; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/Coptisine.html
• Solubility: 10 mM in DMSO
• Smiles: C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6
• Molecular Weight: 320.32
• References & Citations: [1]Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.|[2]He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.|[3]Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.DNA Cell Biol. 2020 Oct 2. |J Oncol. 26 Jun 2022.|SSRN. 2024 Apr 1.|Int Immunopharmacol. 2024 Jan 4:128:111433.|Molecules. 2024 May 14.|Planta Med. 2024 Jun;90(7-08):523-533.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported