Coptisine

• Description:

  Coptisine is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM.

• Product Name Alternative:

  Coptisin

• UNSPSC:

  12352005

• Target:

  Indoleamine 2,3-Dioxygenase (IDO)

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Cancer; Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/Coptisine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6

• Molecular Formula:

  C19H14NO4

• Molecular Weight:

  320.32

• References & Citations:

  [1]Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43 (1) :291-302.|[2]He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50 (2) :185-94.|[3]Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39 (3) :1010428317694565.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  IDO

• Citation 01:

  DNA Cell Biol. 2020 Oct 2.|J Oncol. 2022 Jun 26:2022:9864411.|SSRN. 2024 Apr 1.|Int Immunopharmacol. 2024 Feb 15:128:111433.|Molecules. 2024 May 14.|Naunyn Schmiedebergs Arch Pharmacol. 2025 May;398 (5) :5465-5474.|Phytomedicine. 2025 Oct 21:148:157446.|Planta Med. 2024 Jun;90 (7-08) :523-533.

• CAS Number:

  3486-66-6