Coptisine (chloride)

Coptisine (chloride)

• CAS Number: 6020-18-4
• UNSPSC Description: Coptisine chloride is an alkaloid from Chinese goldthread, and acts as an efficient uncompetitive IDO inhibitor with a Ki value of 5.8 μM and an IC50 value of 6.3 μM. Coptisine chloride is a potent H1N1 neuraminidase (NA-1) inhibitor with an IC50 of 104.6?μg/mL and can be used for influenza A (H1N1) infection.
• Target Antigen: Bacterial; Indoleamine 2,3-Dioxygenase (IDO); Influenza Virus
• Type: Natural Products
• Related Pathways: Anti-infection;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer; Infection; Metabolic Disease
• Assay Protocol: https://www.medchemexpress.com/Coptisine-chloride.html
• Purity: 99.73
• Solubility: DMSO : 10.42 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: C1(C(CC[N+]2=C1C=C(C=C3)C(C4=C3OCO4)=C2)=C5)=CC6=C5OCO6.[Cl-]
• Molecular Weight: 355.77
• References & Citations: [1]Yu D, et al. The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease. J Alzheimers Dis. 2015;43(1):291-302.|[2]He K, et al. The safety and anti-hypercholesterolemic effect of coptisine in Syrian golden hamsters. Lipids. 2015 Feb;50(2):185-94.|[3]Rao PC, et al. Coptisine-induced cell cycle arrest at G2/M phase and reactive oxygen species-dependent mitochondria-mediated apoptosis in non-small-cell lung cancer A549 cells. Tumour Biol. 2017 Mar;39(3):1010428317694565.|[4]Zhou X, et al. Inhibition activity of a traditional Chinese herbal formula Huang-Lian-Jie-Du-Tang and its major components found in its plasma profile on neuraminidase-1. Sci Rep. 2017 Nov 14;7(1):15549.Int Immunopharmacol. 2024 Jan 4:128:111433.|Molecules. 2024 May 14.|Planta Med. 2024 Jun;90(7-08):523-533.|DNA Cell Biol. 2020 Oct 2. |J Oncol. 26 Jun 2022.|SSRN. 2024 Apr 1.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported