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CK-2-68

CAT: 0804-HY-117897-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117897-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CK-2-68 is an inhibitor for complex III in protozoan mitochondrial respiratory chain, by targeting the alternative NADH dehydrogenase (NDH2) of the malarial parasite Plasmodium. CK-2-68 exhibits antimalaria efficacy, that inhibits Plasmodium falciparum infected erythrocytes with an IC50 of 40 nM[1].
CAS Number
1361004-87-6
Product Name Alternative
N-Docosahexaenoyl ethanolamine (DHEA); Docosahexaenoyl ethanolamide
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ck-2-68.html
Purity
98.91
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
O=C1C(C)=C(NC2=C1C=CC(Cl)=C2)C3=CC=C(C=C3)CC4=CC=C(C=C4)OC(F)(F)F
Molecular Formula
C24H17ClF3NO2
Molecular Weight
443.85
References & Citations
[1]Esser L, et al., Structure of complex III with bound antimalarial agent CK-2-68 provides insights into selective inhibition of Plasmodium cytochrome bc1 complexes. J Biol Chem. 2023 Jul;299 (7) :104860.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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