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Anticancer agent 259

CAT: 0804-HY-168730Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168730Size:1 Each
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Description
Anticancer agent 259 (Compound 3g) is a Telmisartan -based cell death modulator, that interfers with the STAT5 signaling pathway, enhances the sensitivity of drug-resistant cells to Imatinib (HY-15463) with SC50 of 1.5 μM[1].
CAS Number
9007-83-4
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/anticancer-agent-259.html
Smiles
O=C(C1=CC=CC=C1C2=CC=C(CN3C(CCC)=NC4=CC=CC=C34)C=C2)OC5=CC=CC=C5
Molecular Formula
C30H26N2O2
Molecular Weight
446.54
References & Citations
[1]Gebhart M, et al., Circumventing Imatinib resistance in CML: Novel Telmisartan-based cell death modulators with improved activity and stability. Eur J Med Chem. 2024 Nov 26;283:117106.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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