Anticancer agent 259

• Description :

  Anticancer agent 259 (Compound 3g) is a Telmisartan (HY-13955) -based cell death modulator, that interfers with the STAT5 signaling pathway, enhances the sensitivity of drug-resistant cells to Imatinib (HY-15463) with SC50 of 1.5 μM[1].

• UNSPSC :

  12352005

• Target :

  STAT

• Type :

  Reference compound

• Related Pathways :

  JAK/STAT Signaling; Stem Cell/Wnt

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/anticancer-agent-259.html

• Smiles :

  O=C(C1=CC=CC=C1C2=CC=C(CN3C(CCC)=NC4=CC=CC=C34)C=C2)OC5=CC=CC=C5

• Molecular Formula :

  C30H26N2O2

• Molecular Weight :

  446.54

• References & Citations :

  [1]Gebhart M, et al., Circumventing Imatinib resistance in CML: Novel Telmisartan-based cell death modulators with improved activity and stability. Eur J Med Chem. 2024 Nov 26;283:117106.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [9007-83-4]