Anticancer agent 259

• UNSPSC Description:

  Anticancer agent 259 (Compound 3g) is a Telmisartan (HY-13955)-based cell death modulator, that interfers with the STAT5 signaling pathway, enhances the sensitivity of drug-resistant cells to Imatinib (HY-15463) with SC50 of 1.5 μM[1].

• Target Antigen:

  STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;Stem Cell/Wnt

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-259.html

• Smiles:

  O=C(C1=CC=CC=C1C2=CC=C(CN3C(CCC)=NC4=CC=CC=C34)C=C2)OC5=CC=CC=C5

• Molecular Weight:

  446.54

• References & Citations:

  [1]Gebhart M, et al., Circumventing Imatinib resistance in CML: Novel Telmisartan-based cell death modulators with improved activity and stability. Eur J Med Chem. 2024 Nov 26;283:117106.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4