AB-680

• Description:

  AB-680 is a highly potent, reversible and selective inhibitor of CD73 (an ecto-nucleotidase), with a Ki of 4.9 pM for hCD73, displays >10,000-fold selectivity over related ecto-nucleotidases CD39. Anti-tumor activity[1].

• UNSPSC:

  12352005

• Target:

  CD73

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/AB-680.html

• Purity:

  99.71

• Solubility:

  DMSO : 100 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=P (CP (O) (O) =O) (O) OC[C@@H]1[C@@H] (O) [C@@H] (O) [C@H] (N2C (N=C (Cl) C=C3N[C@H] (C4=CC=CC=C4F) C) =C3C=N2) O1

• Molecular Formula:

  C20H24ClFN4O9P2

• Molecular Weight:

  580.82

• References & Citations:

  [1]Lawson KV, et al. Discovery and Characterization of AB680, a Potent and Selective Small-Molecule CD73 Inhibitor for Cancer Immunotherapy.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  2105904-82-1