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AB-MECA

CAT: 0804-HY-19365-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-19365-01Size:1 mg
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Description
AB-MECA is a high affinity A3 adenosine receptor agonist with a binding Ki of 430.5 nM for human A3 receptors in CHO cells. AB-MECA can enhance plasma histamine level[1][2][3][4].
CAS Number
152918-26-8
UNSPSC
12352005
Target
Adenosine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/AB-MECA.html
Concentration
10mM
Purity
98.32
Solubility
DMSO : 55 mg/mL (ultrasonic)
Smiles
O[C@H]1[C@H](N2C=NC3=C(NCC4=CC=C(N)C=C4)N=CN=C23)O[C@H](C(NC)=O)[C@H]1O
Molecular Formula
C18H21N7O4
Molecular Weight
399.40
References & Citations
[1]L Yates, et al. Radioligand binding and functional responses of ligands for human recombinant adenosine A (3) receptors. Auton Autacoid Pharmacol. 2006 Apr;26 (2) :191-200.|[2]Solanki, N. D., et al. In Vitro Evaluation Of Anti-Cancer Potential Of A3 Adenosine Receptor Agonist On A549 Human Lung Cancer Cell Line. Int J Pharm Pharm Sci ; 2019 Jun; 11 (6) : 106-108.|[3]X D Ji, et al. A selective agonist affinity label for A3 adenosine receptors. Biochem Biophys Res Commun. 1994 Aug 30;203 (1) :570-6.|[4]Endre G Mikus, et al. Interaction of SSR161421, a novel specific adenosine A (3) receptor antagonist with adenosine A (3) receptor agonists both in vitro and in vivo. Eur J Pharmacol. 2013 Jan 15;699 (1-3) :62-6.|[5]Endre G Mikus, et al. Evaluation of SSR161421, a novel orally active adenosine A3 receptor antagonist on pharmacology models. Eur J Pharmacol. 2013 Jan 15;699 (1-3) :172-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Adenosine A3 receptor (A3R)

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