AB-MECA

• Description :

  AB-MECA is a high affinity A3 adenosine receptor agonist with a binding Ki of 430.5 nM for human A3 receptors in CHO cells. AB-MECA can enhance plasma histamine level[1][2][3][4].

• UNSPSC :

  12352005

• Target :

  Adenosine Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/AB-MECA.html

• Concentration :

  10mM

• Purity :

  98.32

• Solubility :

  DMSO : 55 mg/mL (ultrasonic)

• Smiles :

  O[C@H]1[C@H](N2C=NC3=C(NCC4=CC=C(N)C=C4)N=CN=C23)O[C@H](C(NC)=O)[C@H]1O

• Molecular Formula :

  C18H21N7O4

• Molecular Weight :

  399.40

• References & Citations :

  [1]L Yates, et al. Radioligand binding and functional responses of ligands for human recombinant adenosine A (3) receptors. Auton Autacoid Pharmacol. 2006 Apr;26 (2) :191-200.|[2]Solanki, N. D., et al. In Vitro Evaluation Of Anti-Cancer Potential Of A3 Adenosine Receptor Agonist On A549 Human Lung Cancer Cell Line. Int J Pharm Pharm Sci ; 2019 Jun; 11 (6) : 106-108.|[3]X D Ji, et al. A selective agonist affinity label for A3 adenosine receptors. Biochem Biophys Res Commun. 1994 Aug 30;203 (1) :570-6.|[4]Endre G Mikus, et al. Interaction of SSR161421, a novel specific adenosine A (3) receptor antagonist with adenosine A (3) receptor agonists both in vitro and in vivo. Eur J Pharmacol. 2013 Jan 15;699 (1-3) :62-6.|[5]Endre G Mikus, et al. Evaluation of SSR161421, a novel orally active adenosine A3 receptor antagonist on pharmacology models. Eur J Pharmacol. 2013 Jan 15;699 (1-3) :172-9.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Adenosine A3 receptor (A3R)

• CAS Number :

  [152918-26-8]