Fenbufen-d9

CAT: 0804-HY-B1138S-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1138S-01Size:1 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Fenbufen-d9 (CL-82204-d9) is the deuterium labeled Fenbufen. Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].
CAS Number
[1189940-96-2]
UNSPSC
12352005
Target
Caspase; COX; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Apoptosis; Immunology/Inflammation; Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
C(CCC(O)=O)(=O)C1=C(C(=C(C(=C1[2H])[2H])C2=C(C(=C(C(=C2[2H])[2H])[2H])[2H])[2H])[2H])[2H]
Molecular Formula
C16H5D9O3
Molecular Weight
263.34
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]A E Sloboda, et al. The pharmacological properties of fenbufen. A review. Arzneimittelforschung. 1980;30 (4A) :716-21.|[3]R G Child, et al. Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs, J Pharm Sci. 1977 Apr;66 (4) :466-76.|[4]A E Sloboda, et al. The pharmacology of fenbufen, 3- (4-biphenylylcarbonyl) propionic acid, and 4-biphenylacetic acid, interesting antiinflammatory-analgesic agents. Inflammation. 1976 Dec;1 (4) :415-38.|[5]Asif Husain, et al. Fenbufen based 3-[5- (substituted aryl) -1,3,4-oxadiazol-2-yl]-1- (biphenyl-4-yl) propan-1-ones as safer antiinflammatory and analgesic agents. Eur J Med Chem . 2009 Sep;44 (9) :3798-804.|[6]Christina E Smith, et al. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16;24 (3) :281-292.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-B1138-01Fenbufen
HY-CE01771Fenbufen-CoA
HY-B1138R-01Fenbufen (Standard)
HY-13338S-01Mabuterol-d9
HY-B0228S14Adenosine-d9
HY-B0180S1Imiquimod-d9
HY-17512S4Losartan-d9
HY-B1037S2Salbutamol-d9
HY-W742324SPyriofenone-d9
HY-113266SValerylcarnitine-d9

Alternative Products

CatalogName
011956Fenbufen-d9
M14247-01Fenbufen
A16002-1000Fenbufen 1g
A16002-500Fenbufen 500mg
A16002-100Fenbufen 100mg

Popular Products