Fenbufen

CAT: 0804-HY-B1138-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B1138-01Size:100 mg
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Description
Fenbufen (CL-82204) is an orally active non-steroidal anti-inflammatory drug (NSAID), with analgetic and antipyretic effects. Fenbufen has potent activity in a variety of animal model, including carageenin edema, UV erythema and adjuvant arthritis. Fenbufen has inhibitory activities against COX-1 and COX-2 with IC50s of 3.9 μM and 8.1 μM, respectively. Fenbufen is a caspases (caspase-1, 3, 4, 5, 9) inhibitor[1][2][3][4][5].
CAS Number
[36330-85-5]
Product Name Alternative
CL-82204
UNSPSC
12352005
Hazard Statement
H301
Target
Caspase; COX
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Fenbufen.html
Purity
99.33
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C(O)CCC(C1=CC=C(C2=CC=CC=C2)C=C1)=O
Molecular Formula
C16H14O3
Molecular Weight
254.28
Precautions
H301
References & Citations
[1]A E Sloboda, et al. The pharmacological properties of fenbufen. A review. Arzneimittelforschung. 1980;30 (4A) :716-21.|[2]R G Child, et al. Fenbufen, a new anti-inflammatory analgesic: synthesis and structure-activity relationships of analogs, J Pharm Sci. 1977 Apr;66 (4) :466-76.|[3]A E Sloboda, et al. The pharmacology of fenbufen, 3- (4-biphenylylcarbonyl) propionic acid, and 4-biphenylacetic acid, interesting antiinflammatory-analgesic agents. Inflammation. 1976 Dec;1 (4) :415-38.|[4]Asif Husain, et al. Fenbufen based 3-[5- (substituted aryl) -1,3,4-oxadiazol-2-yl]-1- (biphenyl-4-yl) propan-1-ones as safer antiinflammatory and analgesic agents. Eur J Med Chem . 2009 Sep;44 (9) :3798-804.|[5]Christina E Smith, et al. Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors. Cell Chem Biol. 2017 Mar 16;24 (3) :281-292.|[6]R M Palmer, et al. Effects of the cyclo-oxygenase inhibitor, fenbufen, on clenbuterol-induced hypertrophy of cardiac and skeletal muscle of rats. Br J Pharmacol. 1990 Dec;101 (4) :835-8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Caspase 1; Caspase 3; Caspase 4; Caspase 5; Caspase 9; COX-1; COX-2

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