Losartan-d9

CAT: 0804-HY-17512S4Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-17512S4Size:1 mg
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Description
Losartan-d9 is the deuterium labeled Losartan[1]. Losartan is an angiotensin II receptor antagonist, competing with the binding of angiotensin II to AT1 receptors with IC50 of 20 nM.
CAS Number
[1030937-18-8]
Product Name Alternative
DuP-753-d9
UNSPSC
12352005
Target
Angiotensin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1=NC(Cl)=C(CO)N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2
Molecular Formula
C22H14D9ClN6O
Molecular Weight
431.97
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Burnier, M. Angiotensin II type 1 receptor blockers. Circulation, 2001. 103 (6) : p. 904-12.|[3]Ashry, O., et al. Evidence for expression and function of angiotensin II receptor type 1 in pulmonary epithelial cells. Respir Physiol Neurobiol, 2014.|[4]Choi, C.H., et al. Angiotensin II type I receptor and miR-155 in endometrial cancers: synergistic antiproliferative effects of anti-miR-155 and losartan on endometrial cancer cells. Gynecol Oncol, 2012. 126 (1) : p. 124-31.|[5]Habashi, J.P., et al. Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science, 2006. 312 (5770) : p. 117-21.|[6]Campbell, D.J., et al. Effects of losartan on angiotensin and bradykinin peptides and angiotensin-converting enzyme. J Cardiovasc Pharmacol, 1995. 26 (2) : p. 233-40.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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