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(+) -CBI-CDPI2

CAT: 0804-HY-128881Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-128881Size:1 Each
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Description
(+) -CBI-CDPI2 is an enhanced functional analog of CC-1065. (+) -CBI-CDPI1 is a DNA alkylating agent. (+) -CBI-CDPI2 is an antibody agent conjugates (ADCs) toxin.
CAS Number
128300-15-2
UNSPSC
12352203
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbi-cdpi2.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C2=CC=C3NC(C(N4C5=CC=C6NC(C(N7C[C@](C8)([H])[C@]98C%10=CC=CC=C%10C(C=C79)=O)=O)=CC6=C5CC4)=O)=CC3=C2CC1)N
Molecular Formula
C36H28N6O4
Molecular Weight
608.65
References & Citations
[1]Boger DL, et al. Molecular basis for sequence selective DNA alkylation by (+) - and ent- (-) -CC-1065 and related agents: alkylation site models that accommodate the offset AT-rich adenine N3 alkylation selectivity. Bioorg Med Chem. 1994 Feb;2 (2) :115-35.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Duocarmycins

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