5-Formyl-2'-deoxyuridine

• UNSPSC Description:

  5-Formyl-2'-deoxyuridine is a product formed when the 5-methyl group of thymine in DNA undergoes oxidation due to exposure to gamma radiation or certain chemical agents. Serving as a biomarker of oxidative DNA damage, 5-formyl-2'-deoxyuridine is employed in investigations of DNA damage and repair mechanisms. Additionally, 5-Formyl-2'-deoxyuridine can be used in studies involving chemically crosslinking with peptides derived from the RecA protein[1].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/5-formyl-2-deoxyuridine.html

• Purity:

  99.64

• Solubility:

  DMSO : 200 mg/mL (ultrasonic)

• Smiles:

  OC[C@@H]1[C@@H](O)C[C@H](N2C=C(C=O)C(NC2=O)=O)O1

• Molecular Weight:

  256.21

• References & Citations:

  [1]Sugiyama T, et al. Chemical cross-linking of peptides derived from RecA with single-stranded oligonucleotides containing 5-formyl-2′-deoxyuridine[J]. Nucleosides, Nucleotides and Nucleic Acids, 2001, 20(4-7): 1079-1083.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  4494-26-2