5-Hydroxymethyl-2'-deoxyuridine

• UNSPSC Description:

  5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia[1][2][3].

• Target Antigen:

  HSV

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Cancer; Infection

• Assay Protocol:

  https://www.medchemexpress.com/5-hydroxymethyl-2-deoxyuridine.html

• Purity:

  99.98

• Solubility:

  DMSO : 116.67 mg/mL (ultrasonic)

• Smiles:

  O[C@H]1C[C@H](N2C(NC(C(CO)=C2)=O)=O)O[C@@H]1CO

• Molecular Weight:

  258.23

• References & Citations:

  [1]Shiau GT, et al. Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues. J Med Chem. 1980 Feb;23(2):127-33.|[2]Kahilainen LI, et al. 5-Hydroxymethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cells. Acta Chem Scand B. 1985;39(6):477-84.|[3]JA Vilpo, et al. 5-Hydroxymethyl-2′-Deoxyuridine: Studies of Antileukemic Properties in Vitro and in Vivo. Nucleosides and Nucleotides . 1987.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  5116-24-5