5-Hydroxymethyl-2'-deoxyuridine

5-Hydroxymethyl-2'-deoxyuridine

• CAS Number: 5116-24-5
• UNSPSC Description: 5-Hydroxymethyl-2'-deoxyuridine is a nucleoside analog. 5-Hydroxymethyl-2'-deoxyuridine inhibits the replication of multiple human leukemia cell lines with IC50 values of 1.7-5.8 μM. 5-Hydroxymethyl-2'-deoxyuridine prolongs the survival of mice carrying L1210 leukemia. 5-Hydroxymethyl-2'-deoxyuridine can be used for the research of cell replication and leukemia[1][2][3].
• Target Antigen: HSV
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Cancer; Infection
• Assay Protocol: https://www.medchemexpress.com/5-hydroxymethyl-2-deoxyuridine.html
• Purity: 99.98
• Solubility: DMSO : 116.67 mg/mL (ultrasonic)
• Smiles: O[C@H]1C[C@H](N2C(NC(C(CO)=C2)=O)=O)O[C@@H]1CO
• Molecular Weight: 258.23
• References & Citations: [1]Shiau GT, et al. Synthesis and biological activities of 5-(hydroxymethyl, azidomethyl, or aminomethyl)-2'-deoxyuridine and related 5'-substituted analogues. J Med Chem. 1980 Feb;23(2):127-33.|[2]Kahilainen LI, et al. 5-Hydroxymethyl-2'-deoxyuridine. Cytotoxicity and DNA incorporation studied by using a novel [2-14C]-derivative with normal and leukemic human hematopoietic cells. Acta Chem Scand B. 1985;39(6):477-84.|[3]JA Vilpo, et al. 5-Hydroxymethyl-2′-Deoxyuridine: Studies of Antileukemic Properties in Vitro and in Vivo. Nucleosides and Nucleotides . 1987.
• Shipping Conditions: Room Temperature
• Storage Conditions: 4°C (Powder, protect from light)
• Clinical Information: No Development Reported