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Pep-1 (uncapped)

CAT: 0804-HY-P1848-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1848-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pep-1 (uncapped) is a specific ligand of IL-13Ra2. Pep-1 (uncapped) exerts cell penetrating activity through receptor-mediated endocytosis, can cross the blood-tumor barrier (BTB) and target glioma cells. Pep-1 (uncapped) can enhance the uptake of nanoparticles by tumor cells and enhance the cell penetration ability of nanoparticles, and can be used to develop targeted drug delivery systems for glioma[1].
CAS Number
395069-86-0
UNSPSC
12352209
Target
Interleukin Related
Type
Peptides
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pep-1-uncapped.html
Purity
99.27
Solubility
H2O : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](CCC1)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)C(C)C)=O)=O)=O)=O)=O)=O)[C@H](CCC(N)=O)NC([C@H](CO)NC([C@H](CC2=CNC3=CC=CC=C23)NC([C@H](CCC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CC4=CNC5=CC=CC=C45)NC([C@@H](NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@@H](N)CCCCN)=O)=O)=O)CC6=CNC7=CC=CC=C67)=O)CC8=CNC9=CC=CC=C89)=O)=O)=O)CC%10=CNC%11=CC=CC=C%10%11)=O)=O)=O)=O)=O)=O
Molecular Formula
C136H195N35O33
Molecular Weight
2848.22
References & Citations
[1]Almarwani B, et al. Vesicles mimicking normal and cancer cell membranes exhibit differential responses to the cell-penetrating peptide Pep-1. Biochim Biophys Acta Biomembr. 2018 Jun;1860 (6) :1394-1402.|[2]Wang B, et al. Nanoparticles functionalized with Pep-1 as potential glioma targeting delivery system via interleukin 13 receptor α2-mediated endocytosis. Biomaterials. 2014 Jul;35 (22) :5897-907.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
IL-13

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