Pep-20

CAT: 0804-HY-P11097Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-P11097Size:1 Each

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Description

Pep-20 is a CD47/SIRPα blocking peptide with KD values of 2.91 and 3.63 μM for human and mouse CD47, respectively. IC50 values for blocking the human and mouse CD47/SIRPα interaction are 24.56 and 12.03 μM, respectively. Pep-20 has antitumor activity[1].

CAS Number

3056822-31-9

UNSPSC

12352209

Target

CD47

Related Pathways

Immunology/Inflammation

Field of Research

Cancer

Smiles

O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC8=CNC=N8)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

Molecular Formula

C74H93N21O18

Molecular Weight

1564.66

References & Citations

[1]Wang H, et al. CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy. J Immunother Cancer. 2020 Oct;8 (2) :e000905.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

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