Pep-20

• Description :

  Pep-20 is a CD47/SIRPα blocking peptide with KD values of 2.91 and 3.63 μM for human and mouse CD47, respectively. IC50 values for blocking the human and mouse CD47/SIRPα interaction are 24.56 and 12.03 μM, respectively. Pep-20 has antitumor activity[1].

• CAS Number :

  [3056822-31-9]

• UNSPSC :

  12352209

• Target :

  CD47

• Related Pathways :

  Immunology/Inflammation

• Field of Research :

  Cancer

• Smiles :

  O=C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CO)C(N[C@@H](CC(N)=O)C(N[C@@H](CC5=CC=C(C=C5)O)C(N[C@@H](CC6=CNC7=CC=CC=C67)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC8=CNC=N8)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C)N

• Molecular Formula :

  C74H93N21O18

• Molecular Weight :

  1564.66

• References & Citations :

  [1]Wang H, et al. CD47/SIRPα blocking peptide identification and synergistic effect with irradiation for cancer immunotherapy. J Immunother Cancer. 2020 Oct;8 (2) :e000905.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported