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Stavudine-d4

CAT: 0804-HY-B0116S-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0116S-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Stavudine-d4 is the deuterium labeled Stavudine. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) . Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA) . Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].
CAS Number
1219803-67-4
UNSPSC
12352005
Target
Apoptosis; Autophagy; HIV; Isotope-Labeled Compounds; NOD-like Receptor (NLR) ; Nucleoside Antimetabolite/Analog; Reverse Transcriptase
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Others
Field of Research
Infection
Solubility
10 mM in DMSO
Smiles
O=C1N(C([2H])=C(C(N1)=O)C([2H])([2H])[2H])[C@]2([H])O[C@@H](C=C2)CO
Molecular Formula
C10H8D4N2O4
Molecular Weight
228.24
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Moyle GJ, et al. The role of stavudine in the management of adults with HIV infection. Antivir Ther. 1997;2 (4) :207-218.|[3]Riddler SA, et al. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T) . Antiviral Res. 1995;27 (3) :189-203.|[4]La Rosa F, et al. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019;72 (2) :401-412.|[5]Ferraresi R, et al. Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Lett. 2006;580 (28-29) :6612-6616.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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