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Stavudine

CAT: 0804-HY-B0116-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0116-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) . Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA) . Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].
CAS Number
3056-17-5
Product Name Alternative
D4T
UNSPSC
12352005
Hazard Statement
H341, H373
Target
Apoptosis; Autophagy; HIV; NOD-like Receptor (NLR) ; Nucleoside Antimetabolite/Analog; Reverse Transcriptase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/stavudine.html
Purity
99.87
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)
Smiles
OC[C@H]1O[C@@H](N2C=C(C)C(NC2=O)=O)C=C1
Molecular Formula
C10H12N2O4
Molecular Weight
224.22
Precautions
H341, H373
References & Citations
[1]Moyle GJ, et al. The role of stavudine in the management of adults with HIV infection. Antivir Ther. 1997;2 (4) :207-218.|[2]Riddler SA, et al. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T) . Antiviral Res. 1995;27 (3) :189-203.|[3]La Rosa F, et al. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019;72 (2) :401-412.|[4]Ferraresi R, et al. Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Lett. 2006;580 (28-29) :6612-6616.|[5]Anissa Igoudjil, et al. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antivir Ther. 2007;12 (3) :389-400.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
HIV-1; HIV-2; NLRP3

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