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Stavudine (Standard)

CAT: 0804-HY-B0116R-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B0116R-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Stavudine (Standard) is the analytical standard of Stavudine. This product is intended for research and analytical applications. Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) . Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA) . Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].
CAS Number
3056-17-5
Product Name Alternative
D4T (Standard)
UNSPSC
12352005
Hazard Statement
H341, H373
Target
Apoptosis; Autophagy; HIV; NOD-like Receptor (NLR) ; Nucleoside Antimetabolite/Analog; Reference Standards; Reverse Transcriptase
Type
Reference Standards
Related Pathways
Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; Others
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/stavudine-standard.html
Purity
99.91
Smiles
OC[C@H]1O[C@@H](N2C=C(C)C(NC2=O)=O)C=C1
Molecular Formula
C10H12N2O4
Molecular Weight
224.21
Precautions
H341, H373
References & Citations
[1]Moyle GJ, et al. The role of stavudine in the management of adults with HIV infection. Antivir Ther. 1997;2 (4) :207-218.|[2]Riddler SA, et al. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T) . Antiviral Res. 1995;27 (3) :189-203.|[3]La Rosa F, et al. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019;72 (2) :401-412.|[4]Ferraresi R, et al. Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Lett. 2006;580 (28-29) :6612-6616.|[5]Anissa Igoudjil, et al. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antivir Ther. 2007;12 (3) :389-400.
Shipping Conditions
Room Temperature
Storage Conditions
4°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
Launched

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