EG-011

CAT: 0804-HY-148683-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-148683-01Size:5 mg
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Description
EG-011 is the first-in-class and potent Wiskott-Aldrich syndrome protein (WASP) activator. EG-011 activates the auto-inhibited form of WASP with strong actin polymerization. EG-011 has selective anti-tumor activity in lymphomas[1][2][3].
CAS Number
[2377113-41-0]
UNSPSC
12352005
Target
Arp2/3 Complex
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/eg-011.html
Purity
98.77
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(N1CCCC(C1)N2C(C3=NC=CC=C3N(CC4=CC=C(C=C4)OC5=CC=CC=C5)C2=O)=O)C=C
Molecular Formula
C28H26N4O4
Molecular Weight
482.53
References & Citations
[1]E. Gaudio, et al. EG-011 IS A NOVEL SMALL MOLECULE WITH IN VITRO AND IN VIVOANTI-TUMOR ACTIVITY AGAINST LYMPHOMA. Hematological OncologyVolume 37: 15th International Conference on Malignant Lymphoma Palazzo dei Congressi, Lugano, Switzerland, 18-22 June, 2019.|[2]Filippo Spriano, et al. Abstract 1817: EG-011 is a first-in-class Wiskott-Aldrich syndrome protein (WASp) activator with anti-tumor activity. Cancer Res (2022) 82 (12_Supplement) : 1817. |[3]F. Spriano, et al. The first-in-class WASP activator EG-011 is active in lymphoma and multiple myeloma cell lines resistant to FDA approved compounds. European Journal of Cancer 174S1 (2022) S3-S128.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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