TY-011

CAT: 0804-HY-W395613Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W395613Size:1 Each
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Description
TY-011 is an Aurora A/B kinase inhibitor. TY-011 induces abnormal microtubule-kinetochore attachment, leading to DNA damage and apoptosis (Apoptosis) in human gastric cancer cells, and ultimately inhibits cancer cell proliferation, with an IC50 value ranging from 0.11 to 4.49 μM in human gastric cancer cell lines. TY-011 has potential applications in gastric cancer research[1].
CAS Number
[1389439-77-3]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Aurora Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ty-011.html
Smiles
CC1=C(C(N2)=NN1)N=C(C3=CC=CC=C3Cl)C4=C2C=C(CC)N=C4
Molecular Formula
C18H16ClN5
Molecular Weight
337.81
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Jiang T, et al. Antitumor activity of a novel Aurora A/B kinases inhibitor TY-011 against gastric cancer by inducing DNA damage. Anticancer Drugs. 2020 Jun;31 (5) :440-451.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Aurora A; Aurora B

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